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BioLume®, Inc. is a privately-held biotechnology company located in Research Triangle Park, NC.  Our mission is to develop and commercialize a portfolio of proprietary bioluminescent (light producing) proteins with many first-in-class applications in the food, beverage, cosmetic, and diagnostic imaging markets.
Scientific founder Bruce Bryan, M.D. has discovered, cloned, sequenced, synthesized, and now manufactures a novel portfolio of natural proteins from glowing marine organisms in the deep-sea.  These marine organisms generate light by a chemical reaction known as bioluminescence. These proteins have broad, well-established applications in biomedical research and drug discovery, and are currently in use by many of the largest pharmaceutical companies in the world.

Dr. Bryan’s company, Prolume Ltd, has acquired the world’s largest collection of genetic cDNA libraries and frozen tissues from bioluminescent marine organisms. These tissues have been collected from all over the world and represent a vast genetic resource. Dr. Bryan has cloned, and patented, a number of completely new luciferase genes for exclusive use by Prolume, BioLume, and their partners (see Technology section).

These same genes have clinical potential as diagnostic imaging probes of cancerous tumors.  In principle, this imaging approach allows very early surgical intervention to remove such tumors and metastases.  Considerable published work of the imaging applications by leading academic investigators using Prolume chemistry in laboratory animals has validated this approach.  Furthermore, Prolume has demonstrated the potential of these same “glowing” proteins in a wide variety of food, beverage, and cosmetic applications.

bioLume has the exclusive rights to all diagnostic imaging, and food, beverage, and cosmetic applications of the Prolume technology.

Biolume, Inc.
109 Trellingwood Dr.
Morrisville, NC 27560

Phone: 919-824-9299

Web: http://www.biolume.net

eMail: twillard@biolume.net

Key Search Terms
Bioluminescence, bioluminescence proteins, tissue diagnoses, photonics sensing